alpha-Cyperone

Catalogue number C108700
Chemical namealpha-Cyperone
CAS Number473-08-5
Synonyms(4aS,7R)-1,4a-dimethyl-7-(1-methylethenyl)-3,4,5,6,7,8-hexahydronaphthalen-2-one
Molecular WeightC15H22O
Formula218.3
Purity98%
Physical DescriptionCryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applicationsα-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced expression of inducible COX-2 at both the mRNA and the protein levels. In contrast, α-cyperone had little effect on NO production and iNOS expression. Additionally, α-cyperone downregulated the production and mRNA expression of the inflammatory cytokine IL-6. Moreover, treatment with α-cyperone suppressed the transcriptional activity of NFκB and the nuclear translocation of the p65 NFκB subunit in LPS-induced RAW 264.7 cells.
References1. J. Org. Chem., 1974, 39(17), 2654-2656.
2. J. Org. Chem., 1980, 45(15), 3088-3096.
3. http://www.sciencedirect.com/science/article/pii/S037887411300144X
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alpha-Cyperone
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