Yunaconitine

Catalogue number C108659
Chemical nameYunaconitine
CAS Number70578-24-4
Synonyms11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth
Molecular WeightC35H49NO11
Formula659.7
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsThe anti-inflammatory and analgesic actions of Yunaconitine were reported. When given subcutaneously (10-80μg/kg) or orally (50-100 μg/kg) in rats and mice, Yunaconitine inhibited the increased vascular permeability caused byacetic acid and histamine, the leucocyte migratory response induced by injection of 1 % carrageenin 0.1 ml in rat's thoracic cavity, and the swelling of mouse ear caused by xylene and edema of hind paw elicited by carrageenin, fresh egg white or formaldehyde in intact or in adrenalecto-mized rats. Yunaconitine also showed positive effect in the granuloma inhibition test when it was subcutaneously injected, 10 μg/kg for 6 d, or added directly to the cotton-pellet. That Yunaconitine neither reduced the weights of thymus and adrenal in rats nor prolonged the survival time in adrenalectomized rats indicates that the action of YAc does not depend on stimulation of the pituitary-adreal axis.Assayed with writhing and hot plate method, the median analgesic doses (ED50) of Yunaconitine were found tobe 39 and 42 μg/kg in mice, respectively. Yunaconitine was shown to have antithermic effect in pyrexial rats when administered orally at a dose of 50 μg/kg.
References1. Journal of Pharmaceutical Analysis, 2011, 1(1), 57-59.
2. Acta Botanica Yunnanica, 1998, 20(4), 474-478.
3. J. Nat. Prod., 1986, 49(5), 892-900.
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Yunaconitine
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