Triptolide

Catalogue number C108652
Chemical nameTriptolide
CAS Number38748-32-2
Synonyms(-)-(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-6a-isopropyl-8b-methyltrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Molecular WeightC20H24O6
Formula360.4
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Triptolide has an inhibitory activity on breast, stomach and leukemia cell line HL-60 cells. Triptolide induces apoptosis in tumor cells by blocking NF-KB activation and sensitizing tumor cells for TNF-a induced programmed cell death.


Triptolide has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties limit its therapeutic potential.


Triptolide causes cell growth arrest in certain cell types. It markedly decreases cyst formation in a mouse model of this most common genetic lethal kidney disease. As a potential drug for polycystic kidney disease.

References1. J. Am. Chem. Soc., 1972, 94(20), 7194-7195.
2. J. Am. Chem. Soc., 1982, 104(3), 867-869.
3. Science, 1974, 185(4153), 791-793.
4. Tetrahedron, 2003, 59(23), 4209-4213.
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Triptolide
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SizePrice(USD)Discount
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10mgInquiryN/A
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