Catalogue number C107861
Chemical nameTrifolirhizin
CAS Number6807-83-6
Synonyms(6aR,12aR)-6a,12a-dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-yl beta-D-glucopyranoside
Molecular WeightC22H22O10
Physical DescriptionCryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Its anti-inflammatory activity was examined in lipopolysaccharide (LPS)-stimulated mouse J774A.1 macrophages. Trifolirhizin not only dose-dependently inhibited LPS-induced expression of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), but also inhibited lipopolysaccharide (LPS)-induced expression of cyclooxygenase-2 (COX-2). In addition, trifolirhizin showed in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells. These results suggest that trifolirhizin possesses potential anti-inflammatory and anti-cancer activities.

Compared with kojic acid (16.22+/-1.71 microM), Trifolirhizin possessed potent tyrosinase inhibitory activity with IC(50) values of 506.77+/-4.94 microM. It was further tested for their inhibitory effects on melanogenesis. In cultured B16 melanoma cells, Trifolirhizin markedly inhibited (>50%) melanin synthesis at 50 microM. This is the first study indicating that Trifolirhizin exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.

References1. Natural Product Sciences, 2007, 13(3), 255-257.
2. J. Agric. Food Chem., 2009, 57(11), 4580-4585.
3. Biol Pharm Bull. 2008, 31(1), 154-158.
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