Catalogue number C101760
Chemical nameSqualene
CAS Number111-02-4
Molecular WeightC30H50
Physical DescriptionOil
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsSqualene is an intermediate metabolite in the synthesis of cholesterol. It is transported in serum generally in association with very low density lipoproteins and is distributed ubiquitously in human tissues, with the greatest concentration in the skin, where it is one of the major components of skin surface lipids. Squalene is not very susceptible to peroxidation and appears to function in the skin as a quencher of singlet oxygen, protecting human skin surface from lipid peroxidation due to exposure to UV and other sources of ionizing radiation. Squalene may also act as a "sink" for highly lipophilic xenobiotics. Since it is a nonpolar substance, it has a higher affinity for un-ionized drugs. In humans, squalene might be a useful addition to potentiate the effects of some cholesterol-lowering drugs. The primary therapeutic use of squalene currently is as an adjunctive therapy in a variety of cancers. Although epidemiological, experimental and animal evidence suggests anti-cancer properties, to date no human trials have been conducted to verify the role this nutrient might have in cancer therapy regimens.
References1. Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 46A.
2. Rec. Trav. Chim. (J. R. Neth. Chem. Soc.), 1975, 94, 182.
3. Altern Med. Rev., 1999, 4(1), 29-36.
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