Scutellarin

Catalogue number C108528
Chemical nameScutellarin
CAS Number27740-01-8
Synonyms(2S,3S,4S,5R,6S)-6-[[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-1-benzopyran-7-yl]oxy]-3,4,5-trihydroxy-2-oxanecarboxylic acid
Molecular WeightC21H18O12
Formula462.3
Purity98%
Physical DescriptionYellow powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Scutellarin has been shown to induce apoptosis of ovarian and breast tumor cells in vitro.
Scutellarin binds to site I (subdomain II) mainly by a hydrophobic interaction and there are hydrogen bond interactions between the scutellarin and the residues Arg222 and Arg257.
Scutellarin attenuated H2O2-induced cytotoxicity, intracellular accumulation of ROS and Ca2+, lipid peroxidation, and loss of MMP and DNA, which may represent the cellular mechanisms for its neuroprotective action.


Scutellarin was found to inhibit several strains of HIV-1 replication with different potencies. It appeared to inhibit HIV-1 RT activity, HIV-1 particle attachment and cell fusion. These are essential activities for viral transmission and replication.
Scutellarin has protective effects for cerebral injury through regulating the expression of NOS isoforms and angiogenic molecules.


It has been reported that Scutellarin had neuropro-tective effects on rat brain I/R. Pretreatment with Scutellarin could attenuate hepatocellular damage elicited by brain ischemia/reperfusion in rats and this protection is in major part by its antioxidant activity.

References1. J. Asian Nat. Prod. Res., 2003, 5(4), 249-256.
2. Biomacromolecules, 2004, 5(5), 1956-1961.
3. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 2006, 61(8), 660-663(4).
4. Biomacromolecules,, 2004, 5(5), 1956-1961.
5. Life Sciences, 2004, 74(24), 2959-2973.
6. Biochemical and Biophysical Research Communications, 2005, 334(3), 812-816.
7. Pharmacological Research, 2005, 51(3), 205-210.
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Scutellarin
Price(USD)
SizePrice(USD)Discount
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10mgInquiryN/A
25mgInquiryN/A
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