Saikosaponin B1

Catalogue number C108543
Chemical nameSaikosaponin B1
CAS Number58558-08-0
Synonyms(2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5S,6R)-2-[[(3S,4R,4aR,6aR,6bS,8S,8aS,14bS)-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,14a-dodecahydropicen-3-yl]oxy]-3,5-dihydroxy-6-(hydroxymethyl)-4-oxanyl]oxy]-6-methyloxane-3
Molecular WeightC42H68O13
Formula780.9
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsSaikosaponin A, B1 and D potently stimulated PGE2 release, while saikosaponin B2 and C moderately stimulated PGE2 release. Saikosaponin B1 caused an irreversible elevation of intracellular Ca2+ concentration, which was eliminated by removing extracellular Ca2+. On the other hand, baicalein inhibited saikosaponin B1-induced PGE2 release in a concentration-dependent manner. These results suggest that saikosaponins are activators of PGE2 release, and baicalein is one of the functional inhibitors of PGE2 release by saikosaponins.
References1. Phytochemistry, 1996, 42(6), 1673-1675.
2. Phytochemistry, 1996, 41(3), 895-901.
3. Anal. Chem., 2004, 76(14), 4208-4216.
4. Bioorganic & Medicinal Chemistry Letters, 1997, 7(17), 2193-2198.
5. Biological & Pharmaceutical Bulletin, 1999, 22(12), 1385-1387.
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Saikosaponin B1
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