Mesaconitine

Catalogue number C108655
Chemical nameMesaconitine
CAS Number2752-64-9
SynonymsAconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1α,3α,6α,14α,15α,16β)-
Molecular WeightC33H45NO11
Formula631.7
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Mesaconitine has been reported to have antinociceptive effects via stimulation of the noradrenergic system, inhibits epileptiform field potentials. The inhibitory action of mesaconitine at low concentration is mediated via α-adrenoceptors.


Mesaconitine (MA) inhibited carrageenin-induced hind-paw edema in sham-operated mice as well as adrenalectomized mice. Hind-paw edema produced by subplantar injection, of histamine, serotonin and prostaglandin E1 was suppressed by MA, indicating that it elicits the antiinflammatory activity at the early exudative stage of inflammations.


The antinociceptive action of MA is potentiated through cyclic AMP and stimulation of the central β-adrenergic system.

References1. J. Nat. Prod., 1987, 50(5), 937-939.
2. Chemistry of Natural Compounds, 1985, 21(5), 678-679.
3. Chinese Journal of Chromatography, 2011, 29(5), 430-434.
4. European Journal of Pharmacology, 1985, 108(1), 19-23.
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Mesaconitine
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