| Catalogue number | C108735 |
| Chemical name | Leonurine hydrochloride |
| CAS Number | 24697-74-3 |
| Synonyms | 4-hydroxy-3,5-dimethoxybenzoic acid 4-(diaminomethylideneamino)butyl ester |
| Molecular Weight | C14H21O5N3·HCl·H2O |
| Formula | 311.3 |
| Purity | 98% |
| Physical Description | White cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | To investigate the cardioprotective effects of 10-6 mol/L leonurine on neonatal rat cardiomyocytes treated with hypoxia plus serum deprivation, a component of ischaemia, and to determine the mechanisms underlying the protective effects with regard to cardiac anti-oxidant enzymes and apoptosis genes. Cardiomyocytes were treated with leonurine 8 h prior to exposure to hypoxia. In addition, we investigated the effects of 7.5 and 15 mg/kg leonurine, administered to rats i.p. for 7 days prior to left coronary artery ligation, on subsequent infarct size of the ischaemic heart. Leonurine significantly increased the viability of cardiomyocytes injured by hypoxia. In the leonurine-treated group, gene expression levels of pro-apoptotic genes, namely Bax and Fas, were significantly downregulated (by 0.95- and 0.72-fold, respectively; P < 0.001) compared with the hypoxic control group, whereas the expression of Bcl-2 and Bcl-xl was upregulated following leonurine treatment (by 1.03- and 1.07-fold, respectively; P < 0.05). Correspondingly, leonurine treatment increased Bcl-2 protein levels and decreased Bax protein levels. Assays investigating cardiac anti-oxidant enzymes provided further evidence for a protective effect of leonurine, as indicated by the induction of the anti-oxidant enzymes superoxide dismutase and catalase. Furthermore, leonurine decreased infarct size in ischaemic rat heart. The results of the present study suggest that the mechanisms of action of leonurine in hypoxic neonatal rat cardiomyocytes and infarcted rat heart may be related to its anti-oxidant and anti-apoptotic properties. Leonurine showed a significant inhibited rabbit platelet aggregation induced by thrombin, arachidonic acid, and collagen in vitro with an IC50 of 97.22 μM, 31.03μM, and 44.48μM, respectively. |
| References | 1. Tetrahedron, 1969, 25(21), 5155-5161. 2. Organic Magnetic Resonance, 1980, 14(6), 474–478. 3. Taiwan Pharmaceutical Journal, 2007, 59, 149-152. |
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After Receiving
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Price(USD)
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| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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