| Catalogue number |
C108007 |
| Chemical name | Jaceosidin |
| CAS Number | 18085-97-7 |
| Synonyms | 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;
5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one;
4’,5,7-Trihydroxy-3’,6-dimethoxyflavone |
| Molecular Weight | C17H14O7 |
| Formula | 330.2 |
| Purity | 98% |
| Physical Description | Yellow cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Jaceosidin has been shown to exert anticancer, anti-oxidative, anti-inflammatory, and immunosuppressive effects.
Jaceosidin inhibits the TPA-induced upregulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking extracellular signal-regulated protein kinase-1 and -2 phosphorylation in human breast epithelial cells, which may be indicative of its chemopreventive potential.
Microglia are the innate immune cells in the central nervous system, and they play a central role in the initiation and maintenance of neuroinflammation. We report that jaceosidin inhibits inflammatory activation of microglia, reducing nitric oxide (NO) production and proinflammatory cytokine expression. IC50 for NO inhibition was 27 +/- 0.4 uM. The flavone also attenuated microglial neurotoxicity in the microglia/neuroblastoma co-culture. Systemic injection of jaceosidin ameliorated neuroinflammation in the mouse model of experimental allergic encephalomyelitis. These results indicate that plant flavone jaceosidin is a microglial inhibitor with anti-neuroinflammation activity.
Eupatilin and jaceosidin were also found to moderately inhibit CYP2C19-catalyzed [S]-mephenytoin 4¢-hydroxylation, CYP2D6-catalyzed bufuralol 1¢-hydroxylation, and CYP2C8-catalyzed amodiaquine N-deethylation. Kinetic analysis of human liver microsomes showed that eupatilin is a competitive inhibitor of CYP1A2 with a Ki value of 2.3 mM and a mixed-type inhibitor of CYP2C9 with a Ki value of 1.6 mM. Jaceosidin was shown to be a competitive inhibitor of CYP1A2 with a Ki value of 3.8 mM and a mixed-type inhibitor of CYP2C9 with Ki value of 6.4 mM in human liver microsomes. These in vitro results suggest that eupatilin and jaceosidin should be further examined for potential pharmacokinetic drug interactions in vivo due to inhibition of CYP1A2 and CYP2C9.
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| References | 1. Chemistry of Natural Compounds, 2006, 42(2), 230-231.
2. Ann N Y Acad Sci., 2007, 1095, 458-466.
3. Phytother Res., 2013, 27(3), 404-411.
4. Molecules, 2010, 15(9), 6466-6475.
5. Food Chemistry, 2011, 129(2), 679-683.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 20mg | $195.00 | 5% OFF |
| 50mg | $449.00 | 8% OFF |
| 100mg | $763.00 | 15% OFF |
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