Isoimperatorin

Catalogue number C108614
Chemical nameIsoimperatorin
CAS Number482-45-1
Synonyms4-(3-methylbut-2-enoxy)-7-furo[3,2-g][1]benzopyranone
Molecular WeightC16H14O4
Formula270.2
Purity98%
Physical DescriptionYellow cryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Isoimperatorin inhibits the cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner, with IC50 values of 10.7 microM and 24 microM, respectively. this compound consistently inhibited the production of leukotriene C4 (LTC4), as well as the degranulation reaction in BMMC, with an IC50 value of 5.7 microM and 9 microM, respectively. isoimperatorin has a dual cyclooxygenase-2 selective/5- lipoxygenase inhibitory activity, and therefore may provide the basis for novel anti-inflammatory drugs.


Isoimperatorin possesses a potent hepatoprotective effect against AFB1, presumably through the induction of GSTĪ± and the direct inhibition of CYP1A, and suggest that isoimperatorin should be considered a potential chemopreventive.

References1. Journal of Chromatography A, 2004, 1052, 223-227.
2. Journal of Ethnopharmacology, 2011, 133, 336-344.
3. Arch Pharm Res., 2008, 31(2), 210-215.
4. Carcinogenesis, 2006, 27(12), 2483-2490.
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Isoimperatorin
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10mgInquiryN/A
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