Catalogue number C107956
Chemical nameHesperetin
CAS Number520-33-2
Molecular WeightC16H14O6
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. It inhibits histamine release from IgE-challenged RBL-2H3 cells, with a potency comparable to the commercial anti-allergy drug azelastine. It also reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. The EC50 for these responses is approximately 50 μM.

Hesperetin induces Notch1 expression in carcinoid cells, subsequently suppressing tumor cell proliferation and bioactive hormone production. Notch1 signaling pathway acts as a tumor suppressor in carcinoid tumors. This provides evidence for further study into hesperetin as a potential treatment for carcinoid cancer.

Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.

In the concentration range 250-500 μM, hesperetin and hesperidin showed potent inhibition of LPS-induced expression of the COX-2 gene in RAW 264.7 cells, suggesting the anti-inflammatory activity of these compounds. The ability of hesperetin and hesperidin to suppress COX-2 gene expression may be a consequence of their antioxidant activity.

References1. Pharmaceutical Biology, 2003, 41(7), 546-549.
2. Nig. J. Nat. Prod. and Med., 2000, 4, 57-61.
3. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19), 5784-5786.
4. Am J Surg., 2011, 201(3), 329-332.
5. Anticancer Research, 2005, 25(5), 3367-3374.
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