Catalogue number C108613
Chemical nameGlycitein
CAS Number40957-83-3
Molecular WeightC16H12O5
Physical DescriptionYellow Powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Gycitein has weak estrogenic activity, comparable to that of the other soy isoflavones but much lower than that of DES and 17beta-estradiol.

the effects of genistein, daidzein and glycitein on the growth and DNA synthesis of aortic smooth muscle cells (SMC) from stroke-prone spontaneously hypertensive rats (SHRSP). SMC were cultured in dishes and proliferated on 10% dextran-coated charcoal/fetal bovine serum, and then treated with 0.1–30 μmol/L of genistein, daidzein or glycitein to investigate cell proliferation (cell number) and DNA synthesis (cell proliferation ELISA system), respectively. We also studied their effects on platelet-derived growth factor (PDGF)-BB (20 μg/L)–induced SMC proliferation. Soybean isoflavones inhibited proliferation and DNA synthesis of SMC from SHRSP in a concentration-dependent manner. Inhibition was significant at 3 μmol/L of genistein and 10 μmol/L of both daidzein and glycitein. For significant inhibition of PDGF-BB–induced SMC proliferation, concentrations as low as 0.1 μmol/L of each isoflavone were effective. These isoflavones, with their inhibitory effects on natural and PDGF-BB–induced SMC proliferation, may be useful in attenuatating such proliferation, a basic mechanism involved in atherosclerotic vascular change, thereby preventing atherosclerotic cardiovascular diseases.

References1. Phytochemistry, 1973, 12(1):169-170.
2. J. Nat. Prod., 2003, 66(1):149-151.
3. Tetrahedron, 2004, 60(52):12211-12216.
4. J. Appl. Biol. Chem., 2007, 50(2):63-69.
5. Biomedicine & Pharmacotherapy, 2002, 56(6):302-312.
6. J Agric Food Chem., 1999, 47(4),1607-1610.
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