Ginsenoside Ro

Catalogue number C108563
Chemical nameGinsenoside Ro
CAS Number34367-04-9
SynonymsChikusetsusaponin 5; Chikusetsusaponin V; Polysciasaponin P3;(3beta)-28-(beta-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosiduronic acid
Molecular WeightC48H76O19
Formula957.1
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of acute and chronic hepatitis. Ginsenoside Ro (50 and 200 mg/kg, p.o.) inhibited the increase of serum glutamic oxaloacetic transaminase (s-GOT) and serum glutamic pyruvic transaminase (s-GPT) levels in D-galactosamine (GalN)- and carbon tetrachloride (CCl4)-induced acute hepatitic rats. Ginsenoside Ro inhibited the increase of connective tissue in the liver of CCl4-induced chronic hepatitic rats. Ginsenoside Ro showed a stronger inhibitory effect on the GalN-induced acute hepatitic model than those of the aglycone of ginsenoside Ro, oleanolic acid, or glycyrrhizic acid and its aglycone, glycyrrhetinic acid.


Ginsenoside Ro represents a typical saponin of the family termed glucuronide oleanane-type triterpene carboxylic acid 3,28-O-bisdesmoside (GOTCAB). Such a structure shows no hemolytic nor cytotoxic activities; but is an effective solubilizer for hydrophobic compounds in water. Moreover, ginsenoside Ro demonstrates significant antithrombic, anti-inflammatory, and anti-hepatitis activities in experimental models.

References1. Nat Prod Res., 2010, 24(1), 86-91.
2. Acta Botanica Sinica, 1985, 27(6), 618-624.
3. Synlett, 2004, 2, 259-262.
4. Chem. Pharm. Bull., 1971, 19, 1103.
5. Planta Med., 1991, 57(6), 523-526.
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Ginsenoside Ro
Price(USD)
SizePrice(USD)Discount
5mgInquiryN/A
10mgInquiryN/A
25mgInquiryN/A
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