Ginsenoside Rb3

Catalogue number C108639
Chemical nameGinsenoside Rb3
CAS Number68406-26-8
Synonyms(2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(10R,12S,14R)-12-hydroxy-4,4,10,14-tetramethyl-17-[(E,2R)-6-methyl-2-[[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxy-2-oxanyl]oxymethyl]-2-oxanyl]oxy]oct-5-en
Molecular WeightC53H90O22
Formula1079.2
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Ginsenoside Rb3 possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenosideRb3 at least in part.


Ginsenoside Rb3 could markedly protected OGD-Rep induced ischemic injury and the mechanisms maybe related to its suppression of the intracellular Ca2+ elevation and inhibition of apoptosis and caspase activity. Ginsenoside Rb3 could be a promising candidate in the development of a novel class of anti-ischemic agent.

References1. Natural Product Sciences, 2008, 14(3), 171-176.
2. Chem. Pharm. Bull., 1978, 26, 1694-1697.
3. Molecules, 2007, 12, 2140-2150.
4. European Journal of Pharmacology, 2010, 636(1–3), 121-125.
5. Acta Pharmacologica Sinica, 2010, 31, 273-280.
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Ginsenoside Rb3
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