Ginsenoside F3

Catalogue number C108854
Chemical nameGinsenoside F3
CAS Number62025-50-7
Synonyms(20S)-20-(6-O-α-L-Arabinopyranosyl-β-D-glucopyranosyloxy)-5α-dammara-24-ene-3β,6α, 12β-triol;3β,6α,12β-Trihydroxy-5α-dammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside
Molecular WeightC41H70O13
Formula770.9
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsThe enhancing effect of ginsenoside-F3 on murine spleen cell proliferation was studied using [3H]thymidine incorporation assay. Effects of ginsenoside-F3 on the production of type 1 cytokines IL-2, IFN-γ, and type 2 cytokines IL-4 and IL-10 from murine spleen cells were detected by ELISA method. Effects of ginsenoside-F3 on mRNA level of cytokines IL-4, IFN-γ, and transcription factors T-bet and GATA-3 were evaluated by RT-PCR analysis. Effect of ginsenoside-F3 on NF-κB DNA binding activity in murine spleen cells was investigated by electrophoretic mobility shift assays (EMSA). Ginsenoside-F3 at 0.1-100 µmol/L not only promoted the murine spleen cell proliferation, but also increased the production of IL-2 and IFN-γ, while decreased the production of IL-4 and IL-10 from murine spleen cells with the maximal effect at 10 µmol/L. RT-PCR analysis displayed that ginsenoside-F3 enhanced the IFN-γ and T-bet gene expression and decreased IL-4 and GATA-3 gene expression. EMSA experiment showed that ginsenoside-F3 10 µmol/L enhanced the NF-κB DNA binding activity induced by ConA in murine spleen cells. Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1 cytokines and type 2 cytokines in murine spleen cells.
References1. Acta Pharmacol Sin., 2004, 25(12), 1671-1676.
2. Food Science and Biotechnology, 2010, 19(4), 1119-1122.
3. Chemical and Pharmaceutical Bulletin, 2013, 61(3), 273-278.
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Ginsenoside F3
Price(USD)
SizePrice(USD)Discount
10mg$185.005% OFF
20mg$315.008% OFF
50mg$724.0015% OFF
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