| Catalogue number |
C108565 |
| Chemical name | Ginkgolide J |
| CAS Number | 107438-79-9 |
| Synonyms | 7beta-Hydroxyginkgolide A |
| Molecular Weight | C20H24O10 |
| Formula | 424.4 |
| Purity | 98% |
| Physical Description | Cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Ginkgolide J was discovered in Ginkgo biloba, Ginkgolide J reduces apoptotic damage in cultured chick embryonic neurons.
The ginkgolides B, C, J, M as well as bilobalide react with superoxide and its protonated form as demonstrated by EPR and UV/VIS spectroscopy. The initial reaction rate with these oxygen-derived radicals is in the order of 100 M-1/s and below. It can be suggested that the superoxide scavenging effect of the ginkgolides B, C, J, M and bilobalide contributes to the antioxidant properties of G. biloba.
A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents Aβ1–42 induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by Aβ1–42. This beneficial and multi-faceted mode of action of the ginkgolide makes it a new and promising lead in designing therapies against Alzheimer's disease.
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| References | 1. Phytochemical Analysis, 1993, 4(6), 261-268.
2. J. Nat. Prod., 2002, 65(10), 1501-1504.
3. Phytochemistry, 2004, 65(21), 2897-2902.
4. Pharmacopsychiatry, 2003, 36(1), S8-14.
5. Chemico-biological Interactions, 1997, 106(3), 183-190.
6. Neurobiology of Aging, 2009, 30(2), 257-265.
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| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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