FTY720 Hydrochloride

Catalogue number C233884
Chemical nameFTY720 Hydrochloride
CAS Number162359-56-0
Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; Fingolimod Hydrochloride;
Molecular WeightC18H34ClNO2
Formula343.93
Purity98%
Physical DescriptionWhite Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsFTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
ReferencesBrinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),
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FTY720 Hydrochloride
Price(USD)
SizePrice(USD)Discount
20mg$165.005% OFF
50mg$380.008% OFF
100mg$646.0015% OFF
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