Dehydrocostus lactone

Catalogue number C107925
Chemical nameDehydrocostus lactone
CAS Number477-43-0
Synonyms(3aS,6aR,9aR,9bS)-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
Molecular WeightC15H18O2
Formula230.3
Purity98%
Physical DescriptionCryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Dehydrocostus lactone exhibited strong larvicidal activity against A. albopictus with LC50 values of 2.34 μg/ml


Nitric oxide (NO) and tumor necrosis factor α (TNF-α) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (dehydrocostus lactone) inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-α level in LPS-activated systems in vitro and in vivo. Thus, dehydrocostus lactone may be a possible candidate for the development of new drugs to treat endotoxemia accompanied by the overproduction of NO and TNF-αostus lactone.


In radiorespirometric bioassays against Mycobacterium tuberculosis and Mycobacterium avium, dehydrocostus lactone exhibited minimum inhibitory concentrations of 2 and 16 μg/Ml.

References1. Chemical and Pharmaceutical Bulletin, 2002, 50(11), 1514-1516.
2. Parasitology Research, 2012, 110(6), 2125-2130.
3. Phytochemistry, 1999, 50(6), 967-972.
4. Planta Med., 1999, 65(2), 104-108.
5. J. Nat. Prod., 1998, 61(10), 1181-1186.
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Dehydrocostus lactone
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