DL-Menthol

Catalogue number C108576
Chemical nameDL-Menthol
CAS Number15356-70-4
Synonyms5-methyl-2-propan-2-yl-1-cyclohexanol
Molecular WeightC10H20O
Formula156.2
Purity98%
Physical DescriptionWhite cryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsMenthol's ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation it provokes when inhaled, eaten, or applied to the skin. In this sense, it is similar to capsaicin, the chemical responsible for the spiciness of hot peppers (which stimulates heat sensors, also without causing an actual change in temperature).
Menthol's analgesic properties are mediated through a selective activation of κ-opioid receptors. Menthol also blocks voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles. Menthol also enhances the efficacy of ibuprofen in topical applications via vasodilation, which reduces skin barrier function.
References1. J. Org. Chem., 1995, 60(8), 2423-2429.
2. J. Nat. Prod., 1998, 61(11), 1340-1342.
3. J. Am. Chem. Soc., 1991, 113(11), 4092-4096.
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DL-Menthol
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