Cytisine

Catalogue number C108669
Chemical nameCytisine
CAS Number485-35-8
Synonyms(1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one
Molecular WeightC11H14N2O
Formula190.2
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Cytisine is an acetylcholine agonist, and has strong binding affinity for the nicotinic acetylcholine receptor. As a pharmaceutical preparation, it is available for the treatment of tobacco smoking. It has been available in former socialist economy (FSE) countries for more than 40 years as an aid to smoking cessation under the brand name Tabex produced by the Bulgarian pharmaceutical company Sopharma AD. The synthetic drug varenicline, which has some structural and pharmacological similarities to cytisine, was approved in 2006 as a smoking cessation drug.


In 2011, a randomized controlled trial with 740 patients found cytisine improved 12-month abstinence from nicotine from 2.4% with placebo to 8.4% with cytisine.

References1. Org. Lett., 2000, 2(26), 4201-4204.
2. J. Chem. Soc., Perkin Trans. 2, 1987, 9, 1159-1165.
3. Org. Lett., 2004, 6(4), 493-496.
4. Arch Intern Med., 2006, 166, 1553-1559.
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Cytisine
Price(USD)
SizePrice(USD)Discount
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10mgInquiryN/A
25mgInquiryN/A
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