Coompo Research Chemicals

Crocus sativus L., commonly known as saffron, is used in folk medicine for various purposes. Modern pharmacological studies have demonstrated that saffron extracts have antitumour effects, radical scavenger properties or hypolipaemic effects. Among the constituents of saffron extract, crocetin is mainly responsible for these pharmacological activities. In addition, recent behavioural and electrophysiological studies have demonstrated that saffron extract affects learning and memory in experimental animals. Saffron extract improved ethanol-induced impairments of learning behaviours in mice, and prevented ethanol-induced inhibition of hippocampal long-term potentiation, a form of activity-dependent synaptic plasticity that may underly learning and memory. This effect of saffron extract is attributed to crocin (crocetin di-gentiobiose ester), but not crocetin. Saffron extract or its active constituents, crocetin and crocin, could be useful as a treatment for neurodegenerative disorders accompanying memory impairment.

Crocin has been shown to be a potent antioxidant. It has also been shown to have an anticarcinogenic action. In rodents, crocin has been shown to have antidepressant properties and one study reports aphrodisiac properties.

Crocin inhibitors of pancreatic lipase with an IC50 value of 2.6 mg/ml (triolein as a substrate). Crocin significantly inhibited the increase of serum TG level in corn oil feeding-induced triglyceridemic mice, as well as that of serum triglyceride and total and LDL cholesterol levels in Triton WR-1339-induced hyperlipidemic mice. These compounds also showed hypolipidemic activity in hyperlipidemic mice induced by high cholesterol, high fat or high carbohydrate diets for 5 weeks. The results suggest that the hypolipidemic activity of GF and its component crocin may be due to the inhibition of pancreatic lipase and crocin can improve hyperlipidemia.

1. Biological and Pharmaceutical Bulletin, 2005, 28(11), 2106-2110.
2. Phytother Res., 2000, 14(3), 149-152.
3. Scientia Horticulturae, 2009, 121(3), 366-373.
4. Cancer Letters, 1996, 100(1-2), 22-30.

5. Anticancer Research, 2007, 27(1A), 357-362.