Carnosic acid

Catalogue number C108609
Chemical nameCarnosic acid
CAS Number3650-09-7
Synonyms(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
Molecular WeightC20H28O4
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Carnosic acid has medicinal properties, is a potent antioxidant and protects skin cells against UV-A radiation (photoprotection). Studies in animals have also found a protection against carcinogens. They found that cells treated with carnosic acid triggered antioxidant enzyme production in the cells, which in turn lowered levels of reactive oxygen and nitrogen species (cell-damaging free radicals and peroxides).

carnosic acid substantially inhibited pancreatic lipase activity with IC50 values of 12 μg/mL (36 μM). Carnosic acid significantly inhibited triglyceride elevation in olive oil-loaded mice at doses of 5-20 mg/kg (p.o.). Furthermore, carnosic acid (20 mg/kg/day, p.o.) reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days.

References1. J. Agric. Food Chem., 2001, 49 (11):5560-5565.
2. J. Chromatography A, 1994, 679(2):381-386.
3. Biol. Pharm. Bull., 2003, 26(11):1620-1622.
4. Phytochemistry, 1990, 29(3):994-997.
5. Bioorganic & Medicinal Chemistry Letters, 2004, 14(8), 1943-1946.
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Carnosic acid
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