| Catalogue number |
C104154 |
| Chemical name | Canthin-6-one N-oxide |
| CAS Number | 60755-87-5 |
| Synonyms | |
| Molecular Weight | C14H8N2O2 |
| Formula | 236.2 |
| Purity | 98% |
| Physical Description | Cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Broad spectrum antifungal, leishmanicidal and trypanocidal activities.
Canthin-6-one did not exhibit affinity for sterols, and membrane ergosterol was not necessary for the antifungal activity since the MICs were similar on an ergosterol-deleted and the wild-type S. cerevisiae clones. Relative amount of unsaturated alkyl chain fatty acids was significantly enhanced suggesting a stimulation of desaturase enzyme systems. No synergistic effect was observed between canthin-6-one and amphotericin B, ketoconazole and caspofungine. Canthin-6-one should now be evaluated in vivo against fungal pathogens.
The cytotoxicities of canthin-6-one, 1-methoxycanthin-6-one, 5-methoxycanthin-6-one, and canthin-6-one-3-N-oxide to guinea pig ear keratinocytes have been compared, and the IC50 values range from 1.11 to 5.76 micrograms/ml. There is no significant difference in activity among these four cytotoxic alkaloids.
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| References | 1. Phytochemistry, 2001, 56, 383-386.
2. Chemical & Pharmaceutical Bulletin, 1981, 29(2), 390-395.
3. Journal of Ethnopharmacology, 2011, 133, 986-993.
4. Biomedicine & Pharmacotherapy, 2008, 62(2), 99-103.
5. J. Nat. Prod., 1983, 46(3), 374-378.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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