Calycosin

Catalogue number C108556
Chemical nameCalycosin
CAS Number20575-57-9
SynonymsClycosin;Calycosin;Calycosin(SH);Astraisoflavone;3’-HYDROXYFORMONONETIN;3’,7-DIHYDROXY-4’-METHOXYISOFLAVONE;7,3’-DIHYDROXY-4’-METHOXYISOFLAVONE;7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;3-(3-Hydroxy-4-methoxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one
Molecular WeightC16H12O5
Formula284.2
Purity98%
Physical DescriptionYellow powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro.


Calycosin promotes angiogenesis via activation of MAPK with the involvement of ERK1/2 and ER.
Calycosin acts as a selective estrogen receptor modulator (SERM) to promote angiogenesis, at least in part through VEGF-VEGFR2 and MAPK signaling pathways.


Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM. calycosin dramatically reduced melanin synthesis of Melan-a cells without any apparent cytotoxicity and reduced expression of melanogenic enzyme, tyrosinase. These results suggest that calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes.

References1. Magnetic Resonance in Chemistry, 2006, 44(7), 708-712.
2. Acta Botanica Sinica, 1997, 39(8), 764-768.
3. Magnetic Resonance in Chemistry, 2008, 46(1), 103-106.
4. BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2005, 18, 297-301.
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Calycosin
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