Arctigenin

Catalogue number C108740
Chemical nameArctigenin
CAS Number7770-78-7
Synonyms(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-oxolanone
Molecular WeightC21H24O6
Formula372.4
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Arctigenin is the aglycone of arctiin. It has shown antiviral and anticancer effects.
Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. A new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes. arctigenin might be used as a potential lead compound for the discovery of the agents with mimic exercise training effects to treat metabolic diseases.


Arctigenin selectively promoted glucose-starved A549 tumor cells to undergo necrosis by inhibiting mitochondrial respiration. arctigenin elevated cellular level of reactive oxygen species (ROS) and blocked cellular energy metabolism in the glucose-starved tumor cells. combined arctigenin with the glucose analogue 2-deoxyglucose (2DG) and examined their effects on tumor cell growth. The combination of arctigenin and 2DG may represent a promising new cancer therapy with minimal normal tissue toxicity.


Arctigenin inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-γ and NF-AT.

References1. J. Med. Chem., 1996, 39(1), 86-95.
2. Phytochemistry, 1982, 21(7), 1824-1825.
3. Fitoterapia, 1999, 70(2), 212-213.
4. Biochemical Pharmacology, 2012, 84(4), 468-476.
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Arctigenin
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