Aloeemodin

Catalogue number C107934
Chemical nameAloeemodin
CAS Number481-72-1
Synonyms1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
Molecular WeightC15H10O5
Formula270.2
Purity98%
Physical DescriptionPale yellow powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsAloe emodin has a strong stimulant-laxative action. Aloe emodin is not carcinogenic when applied to the skin, althougth it may increase the carcinogenicity of some kind of radiation.
Aloe-emodin (AE) has a specific in vitro and in vivo antineuroectodermal tumor activity. The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Taking into account its unique cytotoxicity profile and mode of action, AE might represent a conceptually new lead antitumor drug.
Aloe-emodin appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation.
References1. J. Org. Chem., 1980, 45(1), 24-28.
2. Magnetic Resonance in Chemistry, 1992, 30(4), 359-360.
3. Phytochemistry., 1989, 28(12), 3553-3555.
4. Cancer Res., 2004, 64(1), 108-116.
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Aloeemodin
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10mgInquiryN/A
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