Coompo Research Chemicals

Different aspects of the pharmacology of Schisandra chinensis fruit and dibenzo[a,c]cyclooctene lignans from this plant are reviewed focusing in particular on the antihepatotoxic, antioxidant and antitumoural activities, and on the effects on physical performance and on the central nervous system.
Schisantherin A is a mechanism-based inhibitor that not only competitively inhibits but irreversibly inactivates CYP3A4.

The inhibitory action of gomisin C on the respiratory burst is not mediated by changes in cellular cyclic AMP or in inositol phosphates, or by scavenging O2− released from neutrophils, but may be mediated partly by the suppression of NADPH oxidase and partly by the decrease of cytosolic Ca2+ released from an agonist-sensitive intracellular store.