Procyanidin B2

Catalogue number C108764
Chemical nameProcyanidin B2
CAS Number29106-49-8
Synonyms(2R,2’R,3R,3’R,4R)-2,2’-Bis(3,4-dihydroxyphenyl)-3,3’,4,4’-tetrahydro-[4,8’-bi-2H-1-benzopyran]-3,3’,5,5’,7,7’-hexol
Molecular WeightC30H26O12
Formula578.5
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Procyanidin B2 has been shown to inhibit the formation of the advanced glycation end-products pentosidine, carboxymethyllysine (CML), and methylglyoxal (MGO).


Procyanidin B-2 acts as a hair-growing factor in the murine model both in vitro and in vivo. Investigation of the effects of 1% procyanidin B-2 tonic on human hair growth after sequential use for 6 months. A double-blind clinical test involving a total of 29 subjects was performed. Nineteen men in the procyanidin B-2 group and 10 men in the placebo control group were subjected to analyses. No adverse side effects were observed in either group. The hair-growing effect was evaluated using a macrophotography technique combined with measurements of the hair diameter of clipped hairs. The increase in number of total hairs in the designated scalp area (0.5 cm square = 0.25 cm2 area) of procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 6.68 +/- 5.53 (mean +/- SD)/0.25 cm2; placebo, 0.08 +/- 4.56 (mean +/- SD)/0.25 cm2; P < 0.005, two-sample t test). The increase in number of terminal hairs, which are defined as hairs more than 60 microm in diameter, in the designated area (0.5 cm square = 0.25 cm2 area) of the procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 1.99 +/- 2.58 (mean +/- SD)/0.25 cm2; placebo, -0.82 +/- 3.40 (mean +/- SD)/0.25 cm2; P < 0.02, two-sample t test). Procyanidin B-2 therapy shows potential as a safe and promising cure for male pattern baldness.

References1. J. Chem. Soc., Perkin Trans. 1, 1982, 1217-1221
2. J. Agric. Food Chem., 2003, 51(13), 3806-3813
3. Chinese Traditional Patent Medicine, 2007, 29(11), 1645-1647.
4. J. Agric. Food Chem., 2010, 58(11), 6692-6696.
5. Phytomedicine, 2000, 7(6), 529-536.
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Procyanidin B2
Price(USD)
SizePrice(USD)Discount
5mgInquiryN/A
10mgInquiryN/A
25mgInquiryN/A
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