Coompo Research Chemicals

Eupatilin has been known to possess anti-peptic, anti-oxidate, anti-cancer, and anti-allergy activity. The synthetic derivate of eupatilin is called DA-6034.Eupatilin acts as a novel antioxidant and may play an important role in DA-9601-mediated effective repair of the gastric mucosa.

Eupatinil suppresses inflammatory responses by the inhibition of NF-kappaB signaling pathway. As such, many different types of human tumors have misregulated NF-kappaB: that is, NF-kappaB is constitutively active. Active NF-kappaB turns on the expression of genes that keep the cell proliferating and protect the cell from conditions that would otherwise cause it to die via apoptosis.

The topical anti-inflammatory activity of eupatilin was investigated using the inhibition of the Croton-oil-induced dermatitis in the mouse ear as the end point. eupatilin is endowed with potent in vivo topical anti-inflammatory activity, qualitatively similar to that of hydrocortisone and intermediate in terms of potency between those of steroid and non-steroid drugs.