Dihydrotanshinone

Catalogue number C108003
Chemical nameDihydrotanshinone
CAS Number20958-18-3
Synonyms4,8-dimethyl-8,9-dihydronaphtho[2,1-f]benzofuran-7,11-dione
Molecular WeightC18H14O3
Formula278.3
Purity98%
Physical DescriptionRed powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Dihydrotanshinone is a lipophilic component of the medicinal herb Salvia miltiorrhiza (danshen) belonging to the family of Labiatae. The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth and induce caspase-dependent apoptosis concentration-dependently, with dihydrotanshinone being the most potent. All four tanshinones were found to induce ROS generation, but only dihydrotanshinone can induce activation of p38 MAPK. The p38 MAPK activation by dihydrotanshinone was inhibited by N-acetyl cysteine pretreatment. It is thus concluded that ROS-mediated p38 MAPK activation plays a vital role in dihydrotanshinone-induced apoptosis in HepG2 cells.


Dihydrotanshinone relaxed the 5-HT-precontracted coronary artery rings with an IC50 value of 10.39 +/- 1.69µM. None of the above inhibitors or antagonists tested produced a significant change on the vasorelaxant effect of dihydrotanshinone, except 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one caused a 50% reduction. Pre-incubation of the artery rings for 10 min with dihydrotanshinone (100µM) abolished the CaCl2-induced vasoconstriction. These findings suggest that inhibition of Ca2+ influx in the vascular smooth muscle cells is important for the vasorelaxant effect of dihydrotanshinone, and it is independent of pathways involving the endothelium, muscarinic receptors, beta-adrenoceptors, adenylyl cyclase, and guanylyl cyclase. 

References1. Phytochemistry, 1989, 28(11), 3139-3141.
2. Cancer Letters, 2009, 285(1), 46-57.
3. Journal of Ethnopharmacology, 2008, 119(2), 318-321.
Guestbook
  Fill your Email(mail@mail.com)  
After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Featured Products
C262180Verbascoside$72.00/20mg
C108534Isochlorogenic acid A$110.00/20mg
C101591Nodakenetin$214.00/10mg
C104171Curzerenone$374.00/5mg
C234475Echinacoside$72.00/20mg
Dihydrotanshinone
Price(USD)
SizePrice(USD)Discount
10mg$575.005% OFF
20mg$978.008% OFF
50mg$2249.0015% OFF
Orders by E-mail
Orders can be placed by Emails. All orders received will be shipped in the next day if the stock is available.

To place an order, please provide the following information.

1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses

Sent to your order to our email: info@coompo.com
Discount Request
If you have any questions about discounts or dealer discount, please send us a message. We will be glad to help.
Go directly to Coompo product type beginning with
ABC
DEF
GHI
JKL
MNO
PQR
STU
VWX
YZ
  • Contact Us

  •  
  • Email: info@coompo.com
  • Tel: +86-27-84396673
  •  
  • Building B, No.77 Chuangye Rd,
  • Wuhan Economic and Technological Development Zone,
  • Hubei 430056, PRC
  • ©2013-2021 Coompo  |  All rights reserved.