1,2-Dihydrotanshinquinone

Catalogue number C108022
Chemical name1,2-Dihydrotanshinquinone
CAS Number77769-21-2
Synonyms1,6-dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
Molecular WeightC18H14O3
Formula278.3
Purity98%
Physical DescriptionRed powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsSubsequent isolation and structure elucidation yielded the known substances miltirone (1), tanshinone II A (2), 1,2 dihydrotanshinquinone (3), methylenetanshinquinone (4), 1-oxomiltirone (5), 11-hydroxymiltiodiol (6), tanshinone I (7), methyltanshinonate (8), and cryptotanshinone (9). The IC50s of the compounds were determined against the two parasites and rat myoblast (L6) cells. They ranged from 4.1 uM to over 30 uM against P. falciparum K1 strain with selectivity indices (SI) from 0.3 to 1.9. IC50s against T. brucei rhodesiense STIB 900 were from 0.5 uM (1, 4) to over 30 uM, and 4 showed the greatest selective activity with an SI of 24.
References1. Journal of Chromatography A, 1991, 542, 317-326.
2. Med. Res. Rev., 2007, 27(1), 133-148.
3. Planta Med., 2011, 77(14), 1594-1596.
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1,2-Dihydrotanshinquinone
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